NICOTINE EXACERBATES ATHEROSCLEROSIS BY UPREGULATION AND ACTIVATION OF CD36 IN MACROPHAGE

来源 :第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int | 被引量 : 0次 | 上传用户：zhxg1030

【摘要】

：

【作者】

：

Ming-Sheng Zhou Tao Hong Aimei Wang Weihong Li Runxia Tian Keith Webster Leopoldo Raij

【机构】

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Department of Physiology,Liaoning Medical University

【出处】

：

第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int

【发表日期】

：

2013年2期

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Objectives CD36, a class B scavenger receptor expressed on macrophages mediates uptake of oxLDL and contributes to foam cell formation, a hallmark of early atherosclerosis.Tobacco smoking is a major risk factor for atherosclerosis.We investigated a role for the CD36 pathway in nicotine-induced activation of macrophages and foam cell formation in vitro and in ApoE-/-mice in vivo.

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NICOTINE EXACERBATES ATHEROSCLEROSIS BY UPREGULATION AND ACTIVATION OF CD36 IN MACROPHAGE

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