KAPOSIS SARCOMA ASSOCIATED HERPES VIRUS (KSHV) INDUCES DYSREGULATION OF HOST LONG NON-CODING RNAS (L

来源 :17th International Workshop on Kaposi’s Sarcoma Associated H | 被引量 : 0次 | 上传用户:numifan
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LncRNAs are known to be deregulated in diseases like cancers and neurological disorders.Recently, dysregulation of a specific host cellular IncRNA in response to SARS virus infection was reported.KSHV is the etiological agent of Kaposis sarcoma (KS), Primary effusion lymphoma (PEL) and Multi-centric Castlemans disease.During latency KSHV manipulates host cell biology by expressing a subset of viral proteins and 25 miRNAs.HITS-CLIP analysis of Ago in PEL cells identified that IncRNAs constituted a small percentage of the viral miRNA targetome.
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