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It is critically important to maintain acid-base homeostasis in our body.As major carriers for HCO-3 transport, the Na-coupled HCO-3 transporters (NCBTs) of solute carrier 4 family (SLC4) play essential roles in intracellular pH regulation as well as transepithelial HCO-3 movement.Differing in stoichiometry, the NCBTs includes: (1) electrogenic NBCel (SLC4A4) and NBCe2 (SLC4A5); and (2) electroneutral NBCnl (SLC4A7), NBCn2 (SLC4A10), and a Na+-driven Cl-HCO-3 exchanger (NDCBE or SLC4A8).The electrogenic NCBTs carry net charges accompanying ion transport across plasma membrane, whereas the electroneutral ones carry no net charge.