【摘 要】
：
With the acquisition of Esperion in early 2004,the Pfizer Global Biologics group inherited the ETC216 project with a mandate of using the manufacturing process developed by Esperion to generate fresh
【机 构】
：
Technology Lead in the Bioprocess R&D Pfizer Global Biologics USA
【出 处】
：
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
With the acquisition of Esperion in early 2004,the Pfizer Global Biologics group inherited the ETC216 project with a mandate of using the manufacturing process developed by Esperion to generate fresh supply of the drug substance for investigational studies as soon as possible.ETC216 is an HDL mimic complex ofApoA-1M and a phosPholipid with demonstrated reversed cholesterol transport property.The Esperion process for ApoA-1M manufacture was extremely complicated.It consisted of a large number of downstream steps with a complex product recovery scheme from fermentation broth,5 chromatography columns,several ultrafiltration/diafiltration steps,and one reaction step.
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