论文部分内容阅读
Design,synthesis,and structure-activity relationships of Endomorphin-1 analogues containing unnatura
【机 构】
:
Key Laboratory of Preclinical Study for New Drugs of Gansu Province,School of Basic Medical Sciences
【出 处】
:
全国药物化学学术会议暨第四届中英药物化学学术会议
【发表日期】
:
2013年11期
其他文献
Definition of the binding mode of phosphoinositide 3-kinase α-selective inhibitor A-66S through mole
Activation of the phosphatidylinositol 3-kinase α(PI3Kα)is commonly observed in human cancer and is critical for tumour progression,which has made PI3Kα an attractive target for anticancer drug discov
Structure-based drug discovery and design for novel small molecular inhibitors of Sphingomyelin synt
Aim To discover novel small molecular inhibitors of sphingomyelin synthase(SMS)as a tool to study the biological function of sphingomyelin synthase and as a lead compound for new preventive and therap
Dendrimer-assisted formation of self-fluorescent nanogels for simultaneous drug delivery and intrace
会议
格尔德霉素(Geldanamycin,GA)属于苯醌安莎,是重要的抗肿瘤先导化合物.GA 通过竞争性结合Hsp90 N 末端ATP/ADP 结构域,特异性地抑制Hsp90 所必需的ATP 酶活性,从而改变Hsp90 构象,抑制其分子伴侣功能1-2.
Mammalian thioredoxin reductases(TrxRs),including cytosolic TrxR1,mitochondrial TrxR2,and testisspecific TrxR3,belongs to a homodimeric pyridine nucleotide disulfide oxidoreductases [1] and plays an i
Inteins are internal protein elements that self-excise from their host protein and catalyze ligation of the exteins with a peptide bond.
会议
Strategy Toward The Pyridazinone Derivatives:The Synthetic Methodology of New Full-Color Tunable Flu
会议
嘌呤是一类重要的细胞成分,参与生物体内的新陈代谢过程,生命过程中的能量转移,核酸合成以及多种生化反应,其结构骨架广泛应用于药物化学中[1]。
蛋白酪氨酸磷酸酯酶1B(PTP1B)在胰岛素信号通路中起着重要的负调控作用,是治疗Ⅱ型糖尿病和肥胖症的一个潜在靶标。