【摘 要】
：
Malaria still remains one of the major public health problems all over the world[1].Although artemisinin has been used successfully against chloroquine-resistant malarial parasites,its chemotherapeuti
【机 构】
：
Key Laboratory of Structure-Based Drug Design & Discovery(Shenyang Pharmaceutical University),Minist
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Malaria still remains one of the major public health problems all over the world[1].Although artemisinin has been used successfully against chloroquine-resistant malarial parasites,its chemotherapeutic value is limited to a great extent by its shortcomings[2].A large number of artemisinin derivatives were developed,and several C-10 phenoxy derivatives were found to possess excellent anti-malarial activity,especially compound 1[3].It is well known that chloroquine (CQ) was effective in curing all forms of malaria,considered as the mainstay of falciparum malarial chemotherapy for decades.
其他文献
Previous research has indicated that suppressing the tumor cells by inhibiting the binding of MDM2 to p53 with chemical compounds is a worthy endeavor as a new therapeutic strategy for cancer.In hope
Hepatitis C virus(HCV) is the leading cause of liver fibrosis and cirrhosis which eventually worsen to liver cancer.There is urgent need to improve anti-HCV therapies and discover novel therapeutic ap
Inflammation is a local reaction of the vascular and supporting elements of a tissue it is a protective response of the nonspecific immune system that serves to localize,neutralize,or to destroy an in
Thiazolinone and their derivatives are found to be associated with various biological activities such as antifungal,antibacterial,anti-tumor,anti-HIV and anti-inflammatory activities.Organic compounds
A prodrug would undergo enzymatic metabolism to release its active form in vivo.Exploring metabolic process in detail may provide important information about cytotoxicity,hypersensitivity,drug resista
At present,there are more than 20 anti-HIV drugs,which belonged to 6 different classes,approved since the first anti-HIV drug,azidothymidine (AZT)marketed in 1987.1 Among them,NNRTIs are still an impo
Antidepressants and anticonvulsants are among the most widely utilized drugs for the treatment of CNS disorders.Presently some research has revealed that major depression is common in patients with ep
We have synthesized certain 6-substituted 9-methoxy-11H-indeno[1,2-c]quinolin-11-ones for antiproliferative evaluation.Results indicated that 6-alkylamine derivatives,6-[2-(dimethylamino)ethylamino]-9
The prevalence of diabetes throughout the world continues to increase and has become a major health issue.Recently there have been many reports about the inhibitors directed toward the sodium-dependen
The search for potent small molecule protein tyrosine phosphatase 1B inhibitors is a major thrust area in the management of type 2 diabetes mellitus and obesity.A useful and commonly adopted strategy