Longitudinal Modeling and Simulation of the Inhaled Corticosteroid (ICS) Effect on Cortisol Circadia

来源 :第五届定量药理学与新药评价国际会议 | 被引量 : 0次 | 上传用户:misswj2009
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Chronobiology The periodic phenomena in living organisms and their adaptation to solar-and lunar-related rhythms.The CLOCK Disrupted Cortisol Levels Will Lead to…Monitoring Cortisol Change for Safety E.g.:Asthma Treatment using ICS
其他文献
Aims: The purposes of this study were to establish population pharmacokinetic-pharmacodynamic (PopPK-PD) models of S-and R-warfarin in heart valvular replacement (HVR) patients and to provide suggesti
Therapeutic monoclonal antibodies (mAbs) represent a growing segment of the development pipeline in the pharmaceutical industry.Physiologically based pharmacokinetic (PBPK) modeling has been extensive
会议
Background and Aim: Hepatic enzyme CYP2D6 plays an important role in metabolizing many drugs and its genetic polymorphism results in significant individual therapeutic difference.Estimating the phenot
Objective: To investigate the time-dose-response relationship of benvitimod cream after topical administration in patients with mild and moderate psoriasis vulgaris for dosage regimen exploring.Method
Ethical considerations prevent extensive clinical trials in pediatric populations;however, with the use of PBPK modeling, in vivo data from adults can be used to explore the mechanisms of drug disposi
会议
Purpose: Histamine dihydrochloride (HDC) injection has been approved in Europe for the treatment of adults with acute myeloid leukemia (AML), used in combination therapy with the T-cell-derived cytoki
Methodological validations of metabonomic analysis are far from being perfect.This research tends to validate the possibility of Quadrupole linear ion trap (QTRAP) developing into a promising tool in
Background/aim: To establish bioequivalence of lamotrigine dispersible/chewable (CD) tablets (test) versus compressed tablets (reference).Methods: Three clinical studies were conducted in Chinese heal
会议
Introduction The blood-brain barrier(BBB) mainly formed by brain endothelium limits transport of some material from blood to brain to maintain brain homeostasis.P-Glycoprotein(P-GP) acts as a key elem
会议
Discipline development of pharmacometrics (PM)Based on traditional pharmacokinetics 1977: Sheiner, Population pharmacokinetics 1980: NONMEM 1980s: Discipline start 1991: Population pharmacokinetics (A
会议