Human dihydroorotate dehydrogenase(hsDHODH),a flavin-dependent mitochondrial enzyme,plays a rate-limiting role in pyrimidine de novo biosynthesis,which has been identified as a potential target for th
Photodynamic therapy(PDT)that utilized singlet oxygen,generated by light irradiation,to induce cell apoptosis was an novel manner for disease treatment[1-2],in which the building of new structural pho
Human aromatase,also known as CYP19A1,plays an essential role in catalyzing the conversion of androgens to estrogens,and therefore represents one of important drug targets for the treatment of breast
Virtual screening(VS)has become a significant tool in the drug discovery process.In this process,structure-based docking method that considering structure flexibility has attracted researchers attenti