Computational insight into the inhibitory mechanism of azole compounds against aromatase

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：xingzhe009

【摘要】

：

Human aromatase,also known as CYP19A1,plays an essential role in catalyzing the conversion of androgens to estrogens,and therefore represents one of important drug targets for the treatment of breast

【作者】

：

Jinya Cai Guixia Liu Weihua Li Yun Tang

【机构】

：

Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and T

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Aromatase azole inhibitors molecular dynamics inhibitory mechanism

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　　Human aromatase,also known as CYP19A1,plays an essential role in catalyzing the conversion of androgens to estrogens,and therefore represents one of important drug targets for the treatment of breast cancer.

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Computational insight into the inhibitory mechanism of azole compounds against aromatase

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