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SUN domain-containing proteins belong to a novel protein family.To date, several members——SUN1, SUN2, SUN3, and SPAG4——have been identified as nuclear envelope (NE) proteins.In this study, we sought to characterizeand define the potential function of SPAG4L, a newly identified SUN protein.Using bioinformatic analysis, we found that SPAG4L contained a conserved SUN domain in the C-terminal.Subcellular localization analysis indicated that the expression of green fluorescent protein-labeled full-length SPAG4L was localized to the NE and the endoplasmic reticulum (ER).