【摘 要】
：
Astrocytes and microglia are two different types of glial cells,both of which are attracting wide interest in thepain field on account of their roles in the
【机 构】
：
SahlgrenskaAcademyatGteborgUniversitySweden
【出 处】
：
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
Astrocytes and microglia are two different types of glial cells,both of which are attracting wide interest in thepain field on account of their roles in the development,spread,and maintenance of persistent neuropathic pain secondary to peripheral nerve damage,inflammatory neuritis,due to intrathecally induced glial activation.Transmitters released in pain-conducting pathways,such as calcitonin gene-related peptide (CGRP),substance P,and glutamate,together with serotonin (5-HT) released by descending fibers,activate microglia and astrocytes.Besides microglial activation in the spinal cord,a similar transient activation occurs along afferent nociceptive pathways ascending to the thalamus and further to the cortical level.
其他文献
Microvesicles (or microparticles) are a heterogeneous population of phospholipid rich spheres formed from blood and vascular cells during cellular activatio
N-terminal analogs of dermorphin Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 and deltorphin Tyr-D-Ala-Phe-Asp/Glu-Val-Val-Gly-NH2,viz.Tyr-D-Arg-Phe-Lys-NH2 (DALDA) an
Single domain antibodies (sdAbs) are antibody fragments consisting of only one protein domain.A llama sdAb phage display library was screened against non-sm
Neuropeptide Glutamic acid-Isoleucine (NEI) is processed from pre-pro melanin concentrating hormone (ppMCH).In males,the localization of NEI is almost ident
Confidential Patent Pending Introduction:Commercially available lateral flow assays are only qualitative and/or semi-quantitative and can be difficult to mu
Peptidomic studies,i.e.total screening of biological samples for peptides hold considerable promise for elucidating biochemical regulatory networks and for
Parkinsons disease (PD) is the second most common neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia ni
IGF-1 and its binding proteins and receptors are induced within damaged brain regions following ischemia and exogenous administration of IGF-1 after injury
Normally,investigation of a protein-protein interaction is limited to studying how one single molecule interacts with another.However,new evidence shows tha
Transdifferentiation and stem cell fusion with host cells are thought to be the two primary mechanisms of stem cell protection against neuronal injury after