Modulation of Post-ischemia Vimentin and Nestin Expression in the Brain by Umbilical-cord Matrix Ste

来源 :2008中国深圳蛋白质和多肽科学大会 | 被引量 : 0次 | 上传用户：cfzzfz

【摘要】

：

　　Transdifferentiation and stem cell fusion with host cells are thought to be the two primary mechanisms of stem cell protection against neuronal injury after

【作者】

：

Yan Xu Aaron Hirko Renee Dallasen Sachiko Jomura

【机构】

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DepartmentofAnesthesiologyUniversityofPittsburghSchoolofMedicineUSA

【出处】

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2008中国深圳蛋白质和多肽科学大会

【发表日期】

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2008年4期

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　　Transdifferentiation and stem cell fusion with host cells are thought to be the two primary mechanisms of stem cell protection against neuronal injury after ischemic insults.We recently showed that a third novel mechanism of protection through extracellular signaling by the transplanted stem cells might also play a significant role (Jomura et al.,Stem Cells 25:98-106,2007).Transplantation of rat umbilical cord matrix (RUMC) stem cells in one hemisphere before circulatory-arrest-induced global ischemia can greatly reduce hippocampal CA1 neuronal loss in both hemispheres.In this study,we investigated whether this protection is mediated by the stem cells modulation of the inflammation response after global ischemia.

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Modulation of Post-ischemia Vimentin and Nestin Expression in the Brain by Umbilical-cord Matrix Ste

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