【摘 要】
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Objective Transcriptional regulating factor SET, a multitasking protein, is widely expressed in various tissues and mediates diverse biological processes.We previously found that expression of SET gen
【机 构】
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State Key Laboratory of Reproductive Medicine, Nanjing Medical University
【出 处】
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中华医学会第七次全国生殖医学学术会议
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Objective Transcriptional regulating factor SET, a multitasking protein, is widely expressed in various tissues and mediates diverse biological processes.We previously found that expression of SET gene was up-regulated in polycystic ovaries by using microarray.In this study, the effects of SET overexpression and/or silencing on steroidogenic enzyme CYP17al were assessed in ovarian theca cells.Methods Recombinant adenovirus AdCMV-SET and AdSiRNA-SET are constructed to enhance and/or knockdown the expression of SET in thecacells, respectively.
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