Cellular repressor of E1A-stimulated genes antagonizes inflammation and promotes autophagy via lysos

来源 :第17届中国南方国际心血管病学术会议 | 被引量 : 0次 | 上传用户:hesur
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Objective Macrophage inflammation plays an important role in the pathogenesis of atherosclerosis.In this study, we investigated the involvement of cellular repressor of E1A-stimulated genes (CREG) in tumor necrosis factor-α (TNF-α)-induced macrophage inflammation, and explored its inhibitory capacity and mechanisms to assess its potential as a therapeutic reagent for atherosclerosis.
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Bacground Cellular repressor of E1A-stimulated genes (CREG) is a lysosomal glycoprotein implicated in maintaining vascular homeostasis.However, the specific roles and the molecular mechanisms underlyi
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