【摘 要】
：
Fluorinated compounds comprise a substantial proportion in the therapeutic drugs.Its an important strategy to introduce fluorine and fluorinated substitutes in the small molecule for structure-based m
【机 构】
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State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Scienc
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Fluorinated compounds comprise a substantial proportion in the therapeutic drugs.Its an important strategy to introduce fluorine and fluorinated substitutes in the small molecule for structure-based medicinal chemistry.They can modulate the physicochemical and pharmacokinetic properties to improve bioavailability,alter the conformation of a molecule to enhance the selectivities and binding affinity to target proteins,and block metabolically labile sites to increase the metabolic stability of drugs.
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