【摘 要】
：
Pancreatic cancer is one of the leading causes of cancer death.KRAS mutation is present in 95% of human pancreatic ductal adenocarcinoma (PDAC).Transgenic mouse models reveal that KRAS signaling is su
【机 构】
：
Department of Pathology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & P
论文部分内容阅读
Pancreatic cancer is one of the leading causes of cancer death.KRAS mutation is present in 95% of human pancreatic ductal adenocarcinoma (PDAC).Transgenic mouse models reveal that KRAS signaling is sufficient to reprogram pancreatic cells into PDAC, but with a long latency.However, both mutations in KRAS and TP53,INK4a or SMAD4 result in a much earlier appearance of highly invasive and metastatic pancreatic cancer.To further investigate the molecular mechanisms of pancreatic cancer metastasis, we applied a genome-wide random mutagenesis strategy in a lowmetastatic mouse pancreatic cancer cell line Pan02,and implemented series of screening of metastatic conversions from low-metastatic to high metastatic potential using an orthotopic mouse model.
其他文献
Patients with epilepsy are more prone to cognitive and behavioral deficits.Epilepsy per se may induce or exacerbate an underlying psychiatric disorder, a variety of factors contribute to such disorder
The steady-state somatosensory evoked potentials resulted from external constant-frequency vibration stimulation is increasingly becoming a hot research in the field of brain-computer interface in rec
Objective: To observe the therapeutic efficacy in using sulfotanshinone sodium and mecobalamin for treatment of patients with diabetic peripheral peripheral neuropathy.Method: A total of 114 patients
The research adopted intragastric administration to give rats that were bound for five days Shu Yu naloxone and traditional Chinese medicine capsules, and found that ShuYu capsulecan significantly imp
Maillard products are formed by the reaction of sugars and amino groups during the baking and cooking of food causing its browning but also in the human body by intracellularly generated glycolysis in
Purpose: Local progression, in patients with hormone-refractory prostate cancer, often causes significant morbidity.Pelvic radiotherapy (RT) provides effective palliation in this setting, with most pu
The diagnosis of primary central nervous system lymphoma (PCNSL) by radiographical examination is often difficult because of its similarity to other brain tumors.To test whether interleukin-10 (ILl0)
Urine soluble tumor markers have to be validated in its biological environment and the aim of the diagnostic intention.For symptomatic patients hematuria is the predominant factor with more than 90% o
Aim: Due to the rapid development of technology and growing knowledge of radiobiology, radiotherapy is getting stronger everyday as a radical method of cancer treatment.Dose delivery to the target vol
We evaluated the anti-tumor activities of oral administration of fucoidan from Cladosiphon okamuranus in colon26 tumors mice model.The mice administrated intermediate molecular weight fucoidan (IMWF;