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Background: Osteoporosis is the common and severe side effects of glucocorticoid hormone.We analyzed a rare patient with serious osteoporosis who was misdiagnosed as autoimmune polyendocrine syndrome and treated by long term of glucocorticoid hormone and L-thyroxine, in order to clarify the diagnosis of APS and improve the understanding of glucocorticoid-induced osteoporosis (GIOP).