目的 探讨磷酸二酯酶-4选择性抑制剂咯利普兰对淀粉样β蛋白(Aβ)诱导的大鼠脑损伤在抗氧化应激方面的保护作用.方法 采用大鼠脑内微量注射Aβ为Alzheimers 病(AD)动物模型,即SD大鼠双侧海马内分别注射A β25-3510μg.24h后开始用ip给予咯利普兰(0.1,0.5和1.25mg·kg-1),每日1次,持续24 d.注射咯利普兰第14 ～ 15天时用避暗实验测试动物对伤害性电刺激
OBJECTIVE To investigate the effect of dehydro cavidine on behavior and dopamine of striatum in rats, and explore the possible active mechanisms.METHODS Male Sprague Dawley rats, through catalepsies,
OBJECTIVE To study the neuroprotective effects and mechanism of ZY-1 (a derived compound from nicotine) on hippocampal slices insulted by glutamate, NaN3 or H2O2 in vitro.METHODS Different types of mo
Amyloid-β peptides (A β), plays an important role in the pathogenesis of Alzheimer disease (AD).Inflammation is also believed to be integral to the pathogenesis of AD.It was showed that Lipopolysaccha
OBJECTIVE To investigate the potential protec tive effects of corilagin on tert-butyl hydroperoxide (t-BHP)-induced oxidative stress injury in N9 murine microglia cells and elucidate the underlying me
目的 采用高场强核磁共振(phMRI,9.4T)技术,研究左旋四氢帕马丁(l-THP)抑制海洛因成瘾的神经生物学机制.方法 14只健康雄性SD大鼠,重量300 ～ 350 g,建立成瘾模型(第1～3天,海洛因2 mg· kg-1；第4～6天,4mg·kg-1；第7～9天,8 mg·kg-1),d9注射海洛因后纳洛酮4 mg·kg-1诱发出戒断症状则确认.成瘾大鼠随机分为2组,治疗组给予6 dl-T