【摘 要】
：
In early spring 2013,human infections with a novel avian influenza A (H7N9) virus in Eastern China raised concerns of a new influenza pandemic.To address these concerns,the development of a safe and e
【机 构】
：
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Ce
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In early spring 2013,human infections with a novel avian influenza A (H7N9) virus in Eastern China raised concerns of a new influenza pandemic.To address these concerns,the development of a safe and effective H7N9 influenza vaccine is urgently needed.To this end,we generated candidate H7N9 vaccine strains using reverse genetics,with the hemagglutinin and neuraminidase genes derived from a human H7N9 virus and the remaining genes from the PR8 virus,which grows well in eggs.Accordingly,our research was conducted to evaluate recombinant clones in BALB/c mice and ferrets to determine whether the recombinants displayed the characteristics desirable in a vaccine strain,including lower virulence and transmissibility.
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