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5. Design,Synthesis and Biological Evaluation of Thiazolopyrimidin-7-One Derivatives as novel PAM of nA

Design,Synthesis and Biological Evaluation of Thiazolopyrimidin-7-One Derivatives as novel PAM of nA

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：dlfb

【摘 要】

：

Alzheimers disease(AD)is a fatal neurodegenerative disease with the deterioration of cognitive and memory functions.Homologous α7 nicotinic acetylcholine receptors have high calcium permeability,which

【作 者】

：

Wenxuan Jiao Jingshu Tang Geng Peng Yuanheng Li Wenxing Zou Weiqi Kong Jiao Gong Kewei Wang Qi Sun 

【机 构】

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State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking Univer

【出 处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Alzheimer nAChR PAMs synthesis Thiazolo[4 5-d]Pyrimidin-7(6H)-One 

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　　Alzheimers disease(AD)is a fatal neurodegenerative disease with the deterioration of cognitive and memory functions.Homologous α7 nicotinic acetylcholine receptors have high calcium permeability,which regulate the calcium activation and the release of neurotransmitter acetylcholine[1].

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