This paper we take eight water oxygen zirconium chloride as the source of zirconium and polyethylene glycol 20000 as the template agent to acquire WO3/ZrO2,SO4 2-/ZrO2,MoO3/ZrO2,B2O3/ZrO2 and a series of mesoporous solid super acid by using precipitation,and precipitation-impregnation.According to the tests of SEM,TEM,XRD,BET,it shows that these four kinds of catalysts all have certain morphology and relatively ordered mesoporous structures.WO3/ZrO2,which is among the products,has a specific surface area of 80.1772 m2/g,an aperture of 15.96055 nm and a pore volume of 0.252530 cm3/g.At the meantime,these mesoporous solid acid can be used as catalysts into the study of the synthesis of tert-butyl ether glycerin which is formed by the reaction of glycerin and tert-butyl alcohol under a certain conditions.The results showed that if the conditions of the reaction is at glycerin: chloroform = 1:4,temperature is 85oC load 20%,catalyst dosage is 1.14 g,9 h,we can reach the best reaction selectivity and conversion rate,which are respectively 95%and 45%.