Novel Insights into the Molecular Mechanisms of Immune Evasion by HSV-1

来源 :第十届全国病毒学学术研讨会 | 被引量 : 0次 | 上传用户:pang316860297
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  Viral infection initiates a series of signaling cascades that lead to the transcription of interferons (IFNs), which mediate potent innate antiviral response to eliminate viruses.To survive in the host, viruses have evolved intricate strategies to limit secretion of IFNs.Herpes simplex virus 1 (HSV-1) has large genome encoding more than 80 proteins, many of which are previously reported to exhibit immune modulatory capability, such as ICP0, ICP34.5, ICP27, Vhs, etc.
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