【摘 要】
：
Catalytic asymmetric hydrogenation of ketones with chiral transition metal catalysts is one of the most powerful methods for the preparation of chiral alcohols.Chiral 1,2-amino alcohols are very commo
【机 构】
：
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Collaborative I
论文部分内容阅读
Catalytic asymmetric hydrogenation of ketones with chiral transition metal catalysts is one of the most powerful methods for the preparation of chiral alcohols.Chiral 1,2-amino alcohols are very common structural motifs in a wide range of bioactive natural products.The asymmetric hydrogenation of α-amino ketones with chiral rhodium and ruthenium complexes bearing chiral diphosphine ligands has developed for the enantioselective synthesis of chiral 1,2-amino alcohols during the past decades.However, highly efficient chiral catalysts for these transformations are still scarce and the efficiency of this hydrogenation reaction needs to be improved.
其他文献
Ferrocenes, as well as other planar chiral molecules have recently attracted significant attention in the field of both synthetic chemistry, material science and bioorganometallic chemistry.Ferrocene
The indole framework represents one of the most important structural units frequently found in natural products, pharmaceuticals, and other synthetics.1 Among the numerous indole derivatives, polycycl
Quinoxalines are an important class of nitrogen-containing heterocyclesthat possess a broad spectrum of physiological and biological activities.1 Although a number of methods are available for the syn
A novel chiral biphosphine ligands, 6,6-bis(diphenylphosphino)-5,5-biquinoline (BIQAP) was synthesized by two step reactions used optical pure BIQOL as starting material and the molecular structure of
Indole frameworks, especially chiral ones, are widely distributed in a large number of bioactive natural products and pharmaceuticals.1 Owing to the importance of these bioactive indole derivatives, i
Chemoselective control of N-and O-selection is an intriguing issue in nitroso chemistry.1 Recently, we reported an unprecedented asymmetric α-amination of β-ketocarbonyls by coupling of catalytic enam
A chiral capillary electrophoresis method, using sulfated-β-cyclodextrin as chiral selector, was developed for the enantioseparation of glycopyrrolate containing two chiral centers.Several parameters
本文合成了一种新的单一异构体离子型环糊精衍生物-天冬氨酸-β-CD衍生物(A-CD).以A-CD为手性选择剂,用毛细管电泳法对特布他林、氯丙那林、丙卡特罗、妥洛特罗、克伦特罗、卡维地洛6种手性药物进行了对映体分离研究.使用磷酸盐缓冲溶液为背景电解质,考察了手性选择剂浓度、背景电解质pH、缓冲盐浓度对分离的影响,优化了对映体分离条件.结果表明,在pH为2.0、浓度为50 mmol·L-1的磷酸盐缓冲
In recent years, with the rapid development of supramolecular chemistry, small molecule catalysis and supramolecular catalysis based on the principle of molecular recognition and self-assembly have be
The induction, transfer, amplification and memory of chirality are intriguing issues in exploring the origin of homochiral structures in Nature and for possible applications in the various fields such