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目的:观察国产紫杉醇(商品名为特素)联合顺铂治疗晚期非小细胞肺癌的近期疗效及其毒副作用。方法:特素135 mg/m2 加入5% 葡萄糖注射液500 mL,静脉滴注,第1天,DDP 20 mg/m2,静脉滴注,第1天~第5天。以上方案每28 d为1周期,至少完成2周期。结果:CR1例,PR18例,SD17例,PD6例。总有效率45.2 %,主要毒副作用为恶心呕吐、血白细胞减少、脱发、轻度血小板及血红蛋白减少、轻度外周神经感觉异常、肝肾功能轻度损害。结论:国产紫杉醇联合顺铂治疗晚期非小细胞肺癌疗效较好,毒副作用可耐受,值得临床推广应用。
OBJECTIVE: To observe the short-term curative effect and side effects of domestic paclitaxel combined with cisplatin in the treatment of advanced non-small cell lung cancer. Methods: Addition of 135 mg / m 2 of dextrose to 500 ml 5% dextrose injection by intravenous drip, on the first day, DDP 20 mg / m 2 by intravenous drip, from day 1 to day 5. The above program every 28 d for a period of at least 2 cycles completed. Results: CR1 cases, PR18 cases, SD17 cases, PD6 cases. The total efficiency of 45.2%, the main side effects of nausea and vomiting, leukopenia, hair loss, mild reduction of platelets and hemoglobin, mild peripheral nerve sensory abnormalities, liver and kidney function mild damage. Conclusion: Domestic paclitaxel combined with cisplatin in the treatment of advanced non-small cell lung cancer has better curative effect and toxic and side effects, which is worthy of clinical application.