Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, which is characterized by dysregulation of T-cell mediated autoimmunity.NLRP3, a largest and mostly well-studied inflamma-some has been shown to be important in the regulation of adaptive immune response, especially in T cell response.Given the closely association of imbalance of T cell response with ITP, whether NLRP3 is involved in the pathogenesis of ITP remains poorly understood.