Novel anti-AD dimeric leads:from relieving symptoms to modifying diseases via multi-targets

来源 :2019全国老年痴呆与认知障碍相关疾病学术大会 | 被引量 : 0次 | 上传用户：wkxhm123

【摘要】

：

Alzheimer disease(AD)has now become the most common brain disorder among the older population.In addition,the currently existing therapeutics only offer temporary symptomatic relieves.

【作者】

：

HAN Yi-fan HU Sheng-quan Marvin MAK WANG Jia-jun

【机构】

：

State Key Laboratory of Chinese Medicine and Molecular Pharmacology(Incubation),The Hong Kong Polyte

【出处】

：

2019全国老年痴呆与认知障碍相关疾病学术大会

【发表日期】

：

2019年10期

【关键词】

：

Alzheimer disease dimeric leads multi-targets relieving symptoms modifying disea

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Alzheimer disease(AD)has now become the most common brain disorder among the older population.In addition,the currently existing therapeutics only offer temporary symptomatic relieves.

其他文献

CCL21 facilitates chemoresistance and cancer stem cell-like properties of colorectal cancer cells th

Tumor drug resistance is the main reason for the failure of tumor chemotherapy,but the underlying mechanisms are various,which is a big problem in the clinical treatment.A large number of studies have

会议

β-catenin/p300 signaling activation by CBP blockade induces cell senescence in wild-type or T315I-mu

Chronic myeloid leukemia(CML)is a clonal malignant disorder of pluripotent hematopoietic stem cells(HSCs)characterized by the formation of the novel breakpoint cluster region-Abelson tyrosine kinase(B

会议

Activation of GPER suppresses migration and angiogenesis of triple negative breast cancer via inhibi

Triple-negative breast cancer(TNBC)are characterized by high vascularity and frequent metastasis.Here,we found that activation of G protein-coupled estrogen receptor(GPER)by its specific agonist G-1 c

会议

和厚朴酚通过调节c-FLIP抑制EMT介导的肿瘤侵袭作用

会议

GM-CSF诱导结直肠癌转移的作用机制研究

会议

Bisphenol S inactivates Hippo signaling via GPER and promotes the metastasis in triple negative brea

Background: Bisphenol A(BPA)is a chemical with widespread human exposure suspected of causing low-dose effects.Bisphenol-S(BPS)which structurally similar to BPA is intended to replace BPA in plastic.

会议

TNBCBPSFNE-cadVimGPER

XIAP通过调控SOX2维持鼻咽癌干细胞特性及其作为鼻咽癌干细胞治疗靶点的研究

会议

CaMKII通过磷酸化Beclin1调控自噬从而促进Id降解以及神经母细胞瘤细胞分化

会议

Inhibition of 6-phosphogluconate dehydrogenase reverses cisplatin resistance in ovarian and lung can

Cisplatin is currently one of the most effective chemotherapeutic drugs for the treatment of ovarian and lung cancer.Whereas,resistance to cisplatin is common and it often leads to local and distant f

会议

Oct4自噬性降解促进肿瘤干细胞分化的分子机制

会议

Novel anti-AD dimeric leads:from relieving symptoms to modifying diseases via multi-targets

与本文相关的学术论文