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A high-sensitivity Mach-Zehnder(MZ)interferometric refractive index(RI)sensor based on two different ultra-abrupt tapers is proposed and demonstrated experimentally.The whole fabrication process is relatively simple.One taper is fabricated by the fusion-splicing method and the ratio of the waist diameter to the taper length is 1:1.The other taper is fabricated by CO2 laser irradiation with a ratio around 1:10.According to the experimental results,the spectral loss of the proposed MZ interferometric sensor has a linear response to the external RI change with a ultrahigh sensitivity of-412.02138 dB/RIU(refractive index unit)in the range of 1.3505-1.3684.The sensor has the potential application for RI measurement in chemical or biochemical sensing fields due to its low cost,simple structure and extremely high sensitivity.