【摘 要】
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Normal emotional memory system is critical for survival across species.However, when individuals are exposed to the traumatic experience or addictive drugs,
【机 构】
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National Institute on Drug Dependence, Institute of Mental Health, Peking University, Beijing 100191
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Normal emotional memory system is critical for survival across species.However, when individuals are exposed to the traumatic experience or addictive drugs, the emotional memory system is engaged in the pathological learning underlying the related diseases.Our laboratory has been investigating the abnormal synaptic and behavioral plasticity during different pathological memory phases and exploring new pharmacological and behavioral strategies for addiction and post-traumatic stress disorder(PTSD).We discovered that cyclin-dependent kinase 5 activity in basolateral amygdala plays a critical role in the consolidation, retrieval and reconsolidation of cocaine-associated memories protein kinase M zeta is a critical cellular substrate for the maintenance of memories of drug-related cues.
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