Nanomaterials adsorb biomolecules upon contact with all biological environments.Therefore, the biomolecules-coated nanomaterials may need to be considered as ,new materials compared to the pristine nanomaterials during their manufacturing.Particularly, the so called "nanoparticle-protein corona" is expected not only to critically impact nanotoxicology and nanoecology but also influences the success and satety of nanobiomedical applications.