Cancer is an accumulation of a wide range of genomic alterations in normal cells.Advances in the DNA sequence technologies accelerate the large-scale,complete sequencing of cancer genomes.The comprehensive large cancer genome data reveals the evolutionary process that underlies the tumor origin,progression and metastasis, and provides new insights for the treatment of cancers.Thousands of somatically acquired mutations are often associated with solid tumors.However, only a limited number of the mutations, termed as driver mutations, play an important role in driving cancer biology.