Laxaphycin类似物的结构多样性固相全合成及其对人骨肉瘤细胞MG63的抑制活性研究

来源 :中国化学会第十届全国天然有机化学学术会议 | 被引量 : 0次 | 上传用户：yanjie99826

【摘要】

：

近年来,从海洋生物中提取分离得到了多种具有强抗肿瘤活性的环酯肽类化合物,如Laxaphycin等,为抗肿瘤药物研究提供了新的来源和途径.Laxaphycins A(1)和B(2),是Isabelle等从法国波利尼西亚岛地区蓝细菌Lyngbya majuscula中分离得到的两个环酯肽类化合物,其中Laxaphycin B(2)对敏感型(CCRF-CEM)和耐药型(CEB-VLV100和CEM-VM

【作者】

：

钦传光

【机构】

：

西北工业大学理学院应用化学系,西安,710129

【出处】

：

中国化学会第十届全国天然有机化学学术会议

【发表日期】

：

2014年11期

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Laxaphycin类似物的结构多样性固相全合成及其对人骨肉瘤细胞MG63的抑制活性研究

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