【摘 要】
：
I will discuss the role microglia/macrophages may play after intracerebral hemorrhage (ICH) and ischemic stroke in scavenger receptor-mediated oxidative stress, phagocytes and inflammation.Specificall
【机 构】
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University of Texas HSC-Houston USA
【出 处】
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2013百奥泰波兰重大疾病临床峰会
论文部分内容阅读
I will discuss the role microglia/macrophages may play after intracerebral hemorrhage (ICH) and ischemic stroke in scavenger receptor-mediated oxidative stress, phagocytes and inflammation.Specifically, we postulate that pro-phagocytotic behavior of microglia could be achieved in the absence of oxidative stress and inflammation and it could be mediated via activation of transcription factor PPAR*3f or Nrf2.I will demonstrate that specific pharmacologic approaches allow for switching microglia from pro-inflammatory to anti-inflammatory and pro-phagocytotic.We will also show that this strategy could represent a viable approach in combating inflammation, neuronal damage and intraparenchymal hematoma retention after ICH.Finally I will provide some specifics on ongoing clinical trial with pioglitazone for treatment of ICH.
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