A gold-catalyzed tandem cycloisomerization/oxidation of homopropargyl amides has been developed, which provides ready access to synthetically useful chiral γ-lactams with excellent ee by combining the chiral tert-butylsulfinimine chemistry and gold catalysis.The utility of this methodology has also been demonstrated in the synthesis of biologically active eompound S-MPP and natural product (-)-bgugaine.The use of readily available starting materials, a simple nrocedure and mild reaction conditions are other significant features of this method.