New mechanisms of metastatic bone cancer pain: cancer tissue-derived ENDOGENOUS formaldehyde activat

来源 :The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会) | 被引量 : 0次 | 上传用户：lau_lfm

【摘要】

：

　　In recent years, our serial investigations focused on the role of cancer cells-derived endogenous formaldehyde in bone cancer pain.We found that cancer cell

【作者】

：

WANYou[1]TONGZhi-Qian[2]LIYan[3]LIUJia[4]LIUFeng-Yu[5]HANYing[6]

【机构】

：

Neuroscience Research Institute, Peking University, Beijing 100191

【出处】

：

The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会)

【发表日期】

：

2015年期

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　　In recent years, our serial investigations focused on the role of cancer cells-derived endogenous formaldehyde in bone cancer pain.We found that cancer cells produced formaldehyde through demethylation by serine hydroxymethyltransferase (SHMT1 and SHMT2) and lysine-specific histone demethylase 1 (LSD1).

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New mechanisms of metastatic bone cancer pain: cancer tissue-derived ENDOGENOUS formaldehyde activat

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