Death domain-associated protein (Daxx) was originally identified as a protein that specifically binds to the death domain of the transmembrane death receptor FAS (also called CD95) in the cytoplasm and potentiates FAS-induced apoptosis.Overexpression of Daxx enhances Fas-mediated apoptosis and activates the Jun N-terminal kinase (JNK) pathway.Daxx was found in the nuclears where it localizes to promyelocytic leukaemia (PML) oncogenic domains (PODs).As a highly conserved nuclear protein, Daxx plays a important role in proapoptosis, antiapoptosis, transcriptional regulation.This article reviews the latest advances in the study on biological function of Daxx.