Contribution of baicalin on the plasma protein binding displacement and CYP3A activity inhibition to

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：dairui1985

【摘要】

：

【作者】

：

Zhen-yu CHENG Xin TIAN Jie GAO Hong-meng LI Hai-ling QIAO

【机构】

：

Department of Clinical Pharmacology, School of Medicine, Zhengzhou University, Zhengzhou 450052,Chin

【出处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

baicalin nifedipine pharmacokinetics rats plasma protein binding

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Aim: Baicalin purified from the root of Radix scutellariae has been widely used in clinical practices.This study aimed to evaluate the effect of baicalin on the pharmacokinetics of nifedipine, a CYP3A probe substrate, in rats in vivo and in vitro.Methods: Nifedipine (2 mg/kg) was administered to rats immediately following the injection of baicalin (0.225 and 0.45 g/kg) or saline in a Latin-Square design.

其他文献

Effects of Jin Chai antiviral capsule in vivo approach of influenza virus infection through inhibiti

Aim: To investigate the treatment of Jin Chai antiviral capsule for influenza virus PR8/34 (H1N1) infection.Methods: The model of pneumonia was established by dropping influenza virus into the nose of

会议

Jin Chai antiviral capsuleinfluenza virus H1N1NF-κB pathway

Preparation of lung-targeted OMT-PLA-MS and its protective effects on lung injury of mice induced by

Aim: To prepare lung targeted oxymatrine-loaded microspheres, the biodegradeable materials, polylactic acid, was used in the study.Methods: The optimized preparation conditions of oxymatrine polylacti

会议

oxymatrinelung targetinglung injurymicrospheres

Predictions of BuchE inhibitors using support vector machine (SVM) and naive Bayesian classification

Aim: Butyrylcholinesterases (BuChE, EC 3.1.1.8) is emerging as an important pharmacological target in Alzheimers disease (AD) therapy.Due to high cost and laboriousness in experimental tests, it is ne

会议

butyrylcholinesterasesAlzheimer's diseaseSVMBayesianvirtual screening

Identification of key genes related to hypoxia preconditioning by gene-chip and gene network analysi

Aim: To identify the key genes related to hypoxic preconditioning by gene-chip and gene network analysis.Methods: The acute and repetitive hypoxic model in mice and microarray analysis are used to ide

会议

Identification of a novel spinal dorsal horn astroglial D-amino acid oxidase-hydrogen peroxide pathw

Aim: This study investigates the potential role of the spinal astroglial D-amino acid oxidase (DAAO)-hydrogen peroxide pathway in the development of morphine analgesic tolerance.DAAO is a FAD-dependen

会议

D-amino acid oxidasemorphine analgesic tolerancehydrogen peroxidespinal astro

Cannabinoid receptor 2 protects against acute experimental sepsis in mice

Aim: The effects of cannabinoid receptor 2 (CB2R) on the sepsis still remains undefined.Our study is to explore the role and mechanism of CB2R in acute sepsis model of mice.Methods: Survival rate was

会议

cannabinoid receptor 2sepsispro-inflammtory factorproliferationmacrophageT

Structural elucidation of metabolites of lapachol in rats by liquid chromatography-tandem mass spect

Aim: Drug metabolic profile plays an important role in discovering and developing a novel drug from metabolites possessing pharmacological activities.Lapachol is a major active component isolated and

会议

structural elucidationlapacholmetabolitesLC-ESI-MSn

Regulation of CYP3A4/CYP2BG/CYP2C9 transcription through nuclear receptor PXR by helicid and Its met

Aim: To establish and validate an in vitro system to screen drug inducers of CYP3A4,CYP2B6, and CYP2C9 and study hPXR (human pregnane X receptors)-mediated transcriptional regulation of CYP3A4, CYP2B6

会议

helicidhuman pregnane X receptorsCYP3A4CYP2B6CYP2C9

Liquid chromatography-mass spectrometry based metabonomic investigation into the potential biomarker

Aim: To identify and character the biomarkers in mice suffered the repetitive hypoxia.Methods: A metabonomic method utilizing LC-ESI-MSn and multivariate statistical technique has been successfully ap

会议

metabonomicsbiomarkeracute repetitive hypoxiabrainLC-ESI-MS

Assay of plasma protein binding rate of puerarin with microdialysis in vitro tests

Aim: To study the plasma protein binding rate of puerarin.Methods: The microdialysis-HPLC method was applied to determine the plasma protein binding rate of puerarin.Results: The plasma protein bindin

会议

puerarinhigh protein boundingmicrodialysiszero-net fluxHPLC

Contribution of baicalin on the plasma protein binding displacement and CYP3A activity inhibition to

与本文相关的学术论文