【摘 要】
：
The foundation for the adaptive immune system is the ability to recognize a vast array of foreign antigens,a feat accomplished by immunoglobulins and T cell
【机 构】
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UniversityofOklahomaHealthSciencesCenterUSA
【出 处】
：
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
The foundation for the adaptive immune system is the ability to recognize a vast array of foreign antigens,a feat accomplished by immunoglobulins and T cell receptors.The large repertoires of these antigen receptors are produced at the genetic level during B and T cell development by V(D)J recombination,a process that assembles the antigen receptor genes from component gene segments.Recombination events are governed by a conserved DNA sequence,the recombination signal sequence (RSS),which flanks each gene segment.The lymphoid-specific proteins,RAG1 and RAG2,catalyze the initial steps in V(D)J recombination by introducing site-specific DNA double strand breaks at the border between the selected gene segment and its flanking RSS.
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