Our research aim is to understand how Angiotensin Ⅱ type 1 (AT 1) Receptors,and other 7TM receptors,mediate and organize their signalling events,and how they exert their biological function in the cardio-vascular system.During the last decade it has become apparent that the signalling properties of these receptors are very complex.It is known that AT1 Receptors may form both homo-and heterodimers that are pharmacologically distinct,and also that AT 1 receptor can attain different active conformational states which activate distinct signalling pathways.Some of these pathways are inducers of cardiac disease whereas others are protective.Recent data suggest that it is possible use different tool to selective activate (or block) certain signalling pathways.I believe that a thorough investigation of the mechanisms behind this and,the possibilities it provides,will have a large impact drug discovery in the future and it teaches us more about the complex biology of 7TM receptors.