【摘 要】
：
Nectin家族是一类不依赖Ca++的细胞粘附分子.该家族共包含9个成员,4个为nectin (Nec)分子,5个为nectin-I ike (Necl)分子,其主要功能是参与参与细胞粘附,神经突触的形成
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Nectin家族是一类不依赖Ca++的细胞粘附分子.该家族共包含9个成员,4个为nectin (Nec)分子,5个为nectin-I ike (Necl)分子,其主要功能是参与参与细胞粘附,神经突触的形成等.除此之外研究还发现一些病毒侵入细胞的受体分子,如Nec-1是HSV1/HSV2的受体,Nec-2是HSV2及某些HSV1突变体的受体,Nec-4是麻疹病毒的受体,Nec1-5是脊髓灰质炎病毒的受体.Nec/Necl分子同时也充当一些免疫受体分子的配体,参与细胞的免疫调节.然而,多功能的Nec/Necl分子作用机制如何,一直没有确切的答案.在过去的几年中,我们致力于回答这个问题.
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