Signal adaptor sequestosomel/p62 normalizes proliferation of smooth muscle cells and remodeling of t

来源 :International Conference for Physiological Sciences 2012(201 | 被引量 : 0次 | 上传用户：fuchengjun007

【摘要】

：

【作者】

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Tetsuro Ishii

【机构】

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University of Tsukuba,Tsukuba,Ibaraki,Japan

【出处】

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International Conference for Physiological Sciences 2012(201

【发表日期】

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2012年8期

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　　A cytoplasmic adaptor protein sequestosomel/p62 (SQSTMI) plays a key role in receptor-mediated signaling and targeted degradation of ubiquitinated proteins through autophagy.SQSTM 1 is important in metabolic homeostasis/regulation and a phenotype of gene knockout mice is mature-onset obesity accompanied with related diseases, such as hypertension and steatosis.

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Signal adaptor sequestosomel/p62 normalizes proliferation of smooth muscle cells and remodeling of t

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