A New Pathway for the Formation of Nitroxide Radicals from the Reaction between Hydroxamic Acids and

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Desferrioxamine (DFO) is a common drug used for the treatment of iron overload.DFO could protect against DNA single strand breaks induced by tetrachlorohydroquinone (TCHQ).We have shown previously that DFO led to a marked reduction in both the maximum concentration and life span of TCSQ°-during TCHQ autoxidation with the concurrent formation of DFO-nitroxide radical (DFO·).
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