Docking-based virtual screening of large compound libraries has been widely applied to the early stage of lead discovery and is one of the most time-consuming steps in computer aided drug design.
A novel electrochemical sensor for bovine hemoglobin (BHb) recognition and detection was prepared by surface molecularly imprinted technique.Aldehyde groups functionalized silica microspheres were mod
Based on the self-assembly of DNA, serials of asymmetric macrocyclic metallosalen-DNA conjugates have been designed and synthesized, M2L(ClO4)4 (M =Zn2+, Cu2+, Cd2+, Mn2+, Ni2+) (scheme 1), characteri
Small molecule regulators of microRNA could be important tools for the elucidation of the detailed mechanisms ofmiRNA function and could also serve as lead structures for the development of new therap
Proteins are essential components of organisms and are involved in a wide range of biological functions.Protein is also the biomarker of many diseases, however, while in the early stages of disease, t
New Delhi metallo-β-1actmase-1 (NDM-1) has recently attracted extensive attention for its biological activities to catalyze the hydrolysis of almost all of β-1actam antibiotics.[1] In this paper, the