【摘 要】
：
The capability of smart response to the extracellular or intracellular microenviroments,such as overexpressed enzymes,and glutathione and pH differences,has
【机 构】
：
Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of S
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
The capability of smart response to the extracellular or intracellular microenviroments,such as overexpressed enzymes,and glutathione and pH differences,has become a necessary character of the anticancer drug delivery nanovehicles in recent years [1-3].In this work,four pH-responsive DOX-loaded polyion complex (PIC) micelles (noted as SAD,CDAD,CAD and DMMAD) were prepared for adjustable intracellular drug delivery.As shown in Scheme 1,due to the difference in the amide bond linkages,these PIC micelles were proved to have gradient pH-sensitivity in the following order:(a) SAD < (b) CDAD < (c) CAD < (d) DMMAD.As soon as the DOX-loaded micelles finally reached the acidic intmcellular microenvironment,the degradable amide bonds were cleaved with different rates.The negatively charged block copolymers became positively charged,thus the PIC micelles dissociated due to electrostatic repulsion and released the payload with different rates.The in vitro drug release rate was consistent with the sensitivity order of the PIC micelles.The cell uptakes and cytotoxicities of the PIC micelles can also be adjusted by the sensitivities ofcopolymers.
其他文献
该论文通过三元复合体系驱替克拉玛依原油、大庆稀释原油实验;三元复合体系各组分及破乳剂对大庆模型乳状液稳定性的影响;三元复合体系各组分及破乳剂对油水界面张力的影响;
为了解决杂交瘤细胞体外培养时底物代谢效率低,副产物积累严重并妨碍培养水平进一步提高的问题,该文深入研究了分泌抗CEA单抗的杂交瘤细胞株C50的生长代谢规律,全面考察了重
土壤养分特别是N的供应是影响林木生长的重要因素。杉木是我国南方主要的速生用材林树种,在缓解木材紧张供应和保护天然林中起到重要作用。但是,由于杉木生长、轮伐期短,消耗
Boron neutron capture therapy (BNCT) is a binary cancer treatment based upon the high propensity of the nonradioactive nuclide 10B to capture thermal neutro
Localized chemotherapy is routinely used for a number of malignancies [1].As soft materials,hydrogels are perfect candidate for localized drug delivery.Usua
该文针对原燕化公司化工三厂烷基苯装置轻油塔操作严重波动而影响全分离装置的平稳生产问题,进行了操作分析和研究,发现造成生产问题的主要原因是上游脱苯塔操作不良引起的,
Tie self-assembly of amphiphilic copolymers yields nanostructures with a polar core and a hydrophobic shell in non-aqueous solvents,which is commonly referr
疟疾是疟原虫（Plasmodium spp.）感染导致的蚊媒传染性疾病，疟原虫生活周期复杂，经历了多宿主和多细胞形态的转化，每一步都需要精确地基因时空表达调控，转录因子介导的DNA转录水平的
首次尝试对细菌进行高效离子交换色谱.将木糖氧化无色杆菌、肺炎克雷伯氏杆菌? 奇异变形杆菌、普通大肠杆菌、短小芽孢杆菌、变异链球菌、嗜水气单胞菌、金黄色葡萄球菌等作
摘要：随着現代教育技术的发展，多媒体作为一种全新的教学手段，越来越多地走进了课堂。它以其直观、生动、高效的特点，多角度地调动起学生的兴趣、情绪和注意力，给语文教学注入了新的生机与活力。但如果在使用过程中，忽视其“辅助性”，使用不当，反而会有损于教学。本文结合笔者的实践，阐释了多媒体在语文教学中产生的误区，并对科学使用多媒体提出了一些笔者的见解。 关键词：多媒体技术；语文教学；误区；策略 中图分