Mechanisms underlying low [Ca2+](o)-induced increased excitability of hippocampal neurons

来源 :中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the | 被引量 : 0次 | 上传用户:daren19112879
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  Concentration of extracellular calcium ([Ca2+]o) in the central nervous system decreases substantially in different conditions.It results in facilitating neuronal excitability.The goal of this study was to examine the mechanisms underlying enhanced neuronal excitation in low [Ca2+]o in order to provide new clues to treat the hyperexcitability diseases in clinic.Using whole-cell patch-clamp technique,we found that the firing threshold of cultured hippocampal neurons decreased markedly in low [Ca2+]o saline.Unexpectedly,apamine and isoprenaline antagonists of mAHP and sAHP respectively,had no statistic significant effect on excitability of neurons.TTX at a low concentration sufficient to inhibit INaP,blocked the increase of firing frequency in low [Ca2+]o.It also reduced the number of spikes in normal [Ca2+]o.These results suggest that in cultured hippocampal neurons modulation of spiking threshold but not AHP may underlie the increase in excitability in low [Ca2+]o.
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