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  5. Investigation of somatic tumor mutations and single-nucleotide polymorphisms(SNPs) in ATAD5

Investigation of somatic tumor mutations and single-nucleotide polymorphisms(SNPs) in ATAD5

来源 :The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern | 被引量 : 0次 | 上传用户：zhsotanlb
【摘 要】
：
　　The maintenance of genome integrity is important in all cells.To conserve genome integrity, cells developed multiple molecular pathways to repair damaged DN
【作 者】
：
SukhyunKang[1]SuhyeonYoon[2]MisunKang[1]KyooYoungLee[1]DanielleDaee[2]KyungjaeMyung[1] 
【机 构】
：
Center for Genomic Integrity,Institute for Basic Science,Ulsan National Institute of Science and Tec
【出 处】
：
The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern
【发表日期】
：
2015年期
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　　The maintenance of genome integrity is important in all cells.To conserve genome integrity, cells developed multiple molecular pathways to repair damaged DNA.Proliferating Cell Nuclear Antigen (PCNA), which is a homotrimeric ring-structure complex plays an important role in coordinating the replication fork-associated process during the DNA damage response and replication.PCNA functions as a clamp for DNA replication proteins and a platform for multiple DNA repair enzymes.
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