【摘 要】
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Objective: This study was designed to investigate the protective effect of Icariside Ⅱ(ICSⅡ) on the spatial learning and memory impairment in rats induced by streptozotocin (STZ), and further explore
【机 构】
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Department of Pharmacology and the Key Laboratory for Basic Pharmacology of Ministry of Education, Z
【出 处】
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2015全国老年痴呆与认知障碍相关疾病学术大会
论文部分内容阅读
Objective: This study was designed to investigate the protective effect of Icariside Ⅱ(ICSⅡ) on the spatial learning and memory impairment in rats induced by streptozotocin (STZ), and further explore the possible underlying mechanisms.Methods: Eighty male Sprague-Dawley (SD) rats were randomly divided to 4 groups:sham, model, ICS Ⅱ low and high dose groups (n=20).To establish the model with learning and memory impairment, rats were injected with STZ 5 μL (1.5mg/kg) into the bilateral lateral.Low-and high-dose groups were administered by ICS Ⅱ at doses of 3,10 mg/kg on 2th day after STZ for 21 days, while sham and model groups were done with volume-matched vehicle, instead.
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