【摘 要】
：
After basal cell and squamous cell carcinoma, melanoma is the third most common skin cancer in the general population and the most common in young adults aged 25-29 years.At the localized stage, melan
【机 构】
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Department of Dermatology Medical University of Vienna Austria
【出 处】
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2013百奥泰波兰重大疾病临床峰会
论文部分内容阅读
After basal cell and squamous cell carcinoma, melanoma is the third most common skin cancer in the general population and the most common in young adults aged 25-29 years.At the localized stage, melanoma can be cured by surgery.However, at the metastatic stage, it becomes a devastating andincurable disease leading to patients death within a few months to a year.Conventional therapies such as chemotherapy and radiotherapy have shown little success in the treatment of metastasizing melanoma.This necessitates the search for new therapeutic targets to combat melanoma particularly at the advanced stage.Genetic analysis of melanoma has shown this tumor to be a heterogeneous cancer.The most important signaling pathway in melanoma is the mitogen-activated protein kinase (MAPK) pathway, in which two of its members, namely NRAS or BRAF, harbor activating mutations in up to 80% of human melanomas in a mutually exclusive manner.Melanoma responses to BRAFV600E inhibition are often followed by disease recurrence through reactivation of the mitogenactivated protein kinase (MAPK) pathway.Resistance to BRAFV600E inhibition occurs at different levels of this network mainly located upstream to BRAFV600E.Thus, we hypothesized that imhibition of downstream effectors of MAPK signaling or combination with inhibitors of other interacting pathways could be a potential therapeutic strategy.
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