【摘 要】
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Objective: HF-SCS is a novel method ofinspiratory muscle activation and may be a useful method to support artificial ventilation.The purpose of the present study was to evaluate different patterns of
【机 构】
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Department of Physiology and Biophysics Case Western Reserve University USA
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Objective: HF-SCS is a novel method ofinspiratory muscle activation and may be a useful method to support artificial ventilation.The purpose of the present study was to evaluate different patterns of electrical stimulation with HF-SCS in attempt to more closely mimic spontaneous breathing (SB).Methods: In 3 anesthetized dogs, single motor unit (SMU) activity of the diaphragm (D) and parasternal intercostal (P) muscles were assessed during SB and HF-SCS at the T2 level with ramp and non-ramp stimulation by measuring a) time of onset (To) and b) time to peak discharge frequency (TTP).Stimulus amplitude was adjusted to approximate the magnitude of inspired volume observed during SB.To and TTP were determined relative to the onset of inspiratory flow and expressed as a percentage of inspiratory time (Ti).Results: During SB, D was recruited first followed by P; mean onset 8.0±1.1 and 14.2±2.0%Ti, respectively.During non-ramp HF-SCS, To was 1.7±0.7 and 2.4 ±0.3%Ti for D and P, respectively (p<0.05 for each compared to SB).During ramp HF-SCS, To was 13.2±2 and 4.6±0.8 %Ti for D and P (p<0.05 for P for each compared to SB).The discharge frequencies of all SMUs increased during inspiration.Mean peak firing frequencies of D and P were similar during SB, non-ramp and ramp stimulation.During SB, TTP was 74.0± 8.7 and 71.5±6.9%Ti for D and P.During non-ramp HF-SCS, TTP was 10.6±3.1 and 15.8±3.5 %Ti, for D and P (p<0.05 for each compared to SB).During ramp HF-SCS, TTP was 63.0±4.5 and 53.0±3.8 %Ti for D and P (NS for each compared to SB).The pattern of inspiratory flow during ramp stimulation more closely resembled that occurring SB.Conclusion: Activation of the inspiratory motoneuron pools via HF-SCS is responsive to different patterns of electrical stimulation.Ramp-HF-SCS compared to non-ramp HF-SCS results in a more physiologic method of inspiratory muscle activation.
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