【摘 要】
：
雷纳霉素(leinamycin,LNM)在上世纪八十年代末由日本科学家从土壤中的链霉菌株Streptomyces atroolivaceus分离获得. 它由一个十八员环的大环内酰胺和一个含二硫键的五员环螺
【机 构】
：
中南大学湘雅国际转化医学联合研究院湖南省长沙市桐梓坡路172号湘雅医学院新校区办公楼后栋3楼321室
论文部分内容阅读
雷纳霉素(leinamycin,LNM)在上世纪八十年代末由日本科学家从土壤中的链霉菌株Streptomyces atroolivaceus分离获得. 它由一个十八员环的大环内酰胺和一个含二硫键的五员环螺合在一起,具有非常新奇的结构和优异的抗癌活性.对雷纳霉素生物合成和半合成的研究将帮助我们理解杂和聚酮/肽的生物合成机理和含二硫键的五员环形成可能涉及的新化学问题,以及产生可能具有新活性的衍生物.
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