The paper aims to analyze the possibility of application of initiated chemiluminscence (ICL) method to monitoring of treatment of oncological processes in mucous membrane of mouth and larynx.It was confirmed, that ICL can be used in this case as inexpensive and highly informative express-method.We use the induction of chemiluminsence by hydrogen peroxide with iron sulfate (Ⅱ).In order to check the possibility of application of this method, 248 experiments on the analysis of the chemiluminescence of blood serum of persons with oncological diseases of mucous membranes were performed as well as and 306 experiments with healthy people as a control group.Patients with oncological deceases were divided into 5 groups: 《before medical treatment》, 《one month after the radical sergury》, 《after irradiation》, 《patients without evidence of tumour progression (after treatment)》, 《patient with recurrent tumour》.All results obtained are compared with data of ICL of healthy people that form the control group.The main attention is paid to analysis of chemiluminograms with two maxima.The statistical analysis of such a type of chemiluminograms is performed in different groups of patients.